Name: Kolibri – The Digital Mesh Nebulizer System for Inhaled Drug Delivery
SKU: eaa6f819-fc59-4b11-b2de-d615f23b5f07

Pharmaceutical, Inhalation

Aptar Pharma has been providing customers with innovative drug delivery systems and services for orally inhaled and nasal drug product (OINDP) for decades. With a drug delivery system portfolio covering a wide range of inhalation and nasal drug delivery technologies, the company continues to expand its drug delivery offering.

Through the partnership with PULMOTREE, Aptar Pharma can now proudly propose the Kolibri vibrating mesh nebulizer system. Kolibri’s design includes the innovations and digital features required to meet today’s inhaled drug delivery specifications

Kolibri – The Digital Mesh Nebulizer
System for Inhaled Drug Delivery

Aptar Pharma’s Kolibri drug delivery system is a NPLI (Non-Propellant Liquid Inhaler) and packed with new features and technologies that help to elevate the inhalation system to new standards through connectivity and convenience.

Aptar Pharma’s Kolibri system is a breath triggered vibrating mesh aerosolization nebulizer with unique guidance capabilities that can enhance drug deposition to specific areas of the lungs. Kolibri is a portable, efficient nebulizer system that provides patients and researchers with delivery of targeted medications to the lungs.

Aptar Pharma’s Kolibri Nebulizer: Advancing Inhalation Technology

Single black cylindrical Kolibri mesh nebulizer (NPLI) on charging mount with digital data connectivity by Aptar.

Kolibri Inhalation Performance

The Kolibri Nebulizer or Non-Propellant Liquid Inhaler (NPLI) platform provides precise drug delivery to targeted areas of the lungs.
Patient Training and Guidance

The Kolbri system provides haptic feedback to the patient, guiding the breathing pattern for optimal delivery.
Integrated e-Health Nebulizer Technology

Digital Kolibri Nebulizer systems generate therapy data that can be automatically uploaded to the cloud, supporting patient treatment and clinical research.
Customizable and Patient Centric Nebulizer Technology

The Kolibri mesh nebulizer is available in a range of colors for product differentiation and its performance can be customized for specific medications, patient groups and market strategies.
Intelligent Administration System (iNAS)

The Kolibri’s iNAS delivers optimized drug deposition to target areas of the lung via inspiratory flow controls with detailed use data.
Key & Lock System for Product and Patient Protection

Both the product and patient are protected by Kolibri’s Key & Lock System. It blocks the use of non-original aerosol head and tracks the useful life of this critical component.
Kolibri Clinical Research Applications

The unique Connect-Web-Interface provides data and controls that make study participant management easier. With detailed user and system data, Kolibri helps clinical researchers to support the validity of clinical study data in real-time.

Three cylindrical Aptar Kolibri portable mesh nebulizer NPLIs, in blue, black and grey, standing at an angle for inhalation.

Kolibri Inhalation Performance

Aptar Pharma’s Non-Propellant Liquid Inhaler (NPLI) platform provides targeted drug delivery to specific areas of the lungs. The breath triggered inhalation control technology ensures doses are administered with ease and only when the user is inhaling. The aerosol generator system can be tailored for optimized performance when delivering specific drug molecules. The sleek, cylindrical design with an integrated mouthpiece, houses specialized digital technology that automatically uploads device data to the cloud for review and analysis.

Kolibri also provides both haptic and digital inhalation feedback, that helps to eliminate user error. All of these innovative features combine to produce a simple, reliable and portable nebulizer system that can deliver a variety of liquid drug formulations to targeted regions of the patient’s lungs.

Black Aptar Kolibri inhaler on charging mount with mouthpiece beside digital data tracking app.

e-Health Inhalation Technology

The Kolibri nebulizer system offers features that deliver data driven performance like nothing before. The smart system automatically stores digital therapy data via a data exchange for that is encoded safety and security. This stored data is useful for patient adherence monitoring and can even help determine the quality of the inhalation activity achieved by the user.
Kolibri generates and saves data regarding:

Inhalation technique
Inspiratory flow
Inhaled volume
Administration status
Time/date
Device status/battery power
Aerosol generator life-meter

This detailed nebulizer inhalation data can also be used to support reliable clinical study results for products under development. It can also help physicians or researchers to optimize patient therapy regimens that improve patient outcomes. With Aptar Pharma’s Kolibri vibrating mesh nebulizer, patients can now receive accurate use and compliance feedback without invasive in-person assessments. Longer term monitoring via Kolibri’s data collection functions can provide Health Care Professionals (HCPs) with the insights needed to provide patients with timely interventions for improved health.

Kolibri Nebulizer Connect App

The Kolibri Connect App can be loaded onto most smartphones and provide users with a single interface for digital nebulizer data. From therapy reminders to dosing planning, the Connect App helps HCPs and patients stay on the prescribed treatment regimen. The app also provides the user with a personal therapy diary with access to the entire therapy plan history.

In addition to maintaining use data, the Kolibri Connect App also conveniently shares inhalation technique feedback with the user in real-time for optimal drug deposition. The connectivity features of Kolibri also allow centralized therapy control and the integration of additional medications and compatible digital devices into one system.

Top view of black cylindrical Kolibri soft mist inhaler (SMI) showing oval inhalation mouthpiece for lung delivery.

Customizable and Patient Centric

The Kolibri mesh nebulizer system provides flexible performance and unique customization options. Because it is based on a programmable digital control system, the Kolibri can be customized for user-specific medication, patient group and market strategies. Aerosol head tuning is possible to optimize Kolibri’s output for each individual drug formulation. The user can visually view real time feedback on the connect app regarding inhalation flow, so that they know if their inhalation is within required specifications to deliver the drug product to dose. If the inhalation flow is out of range, the user will receive a color-coded notice.

Aptar Pharma’s Kolibri vibrating mesh nebulizer also provides direct haptic feedback through the system. The system vibrates distinctively to signal when the user’s inspiration is either too high or within the specified range. This enables the Kolibri nebulizer to respond to the individual patient’s inspiration and inhalation capabilities and let them know if their inhalation maneuver is going to provide optimal drug delivery. Available in three different colors, the Kolibri system provides pharmaceutical companies with brand differentiation opportunities.

Side view of black cylindrical Aptar Kolibri NPLI above corded base used to deliver liquid droplets to lungs.

Intelligent Administration System (iNAS)

Our Intelligent Administration System (iNAS) delivers optimized drug deposition inspiratory flow control. The fully automated system releases the aerosol in the most therapeutically useful phase of inspiration. The integrated feedback loop, available through the Kolibri Connect app, provides the user with direct feedback regarding their specific inhalation technique, and inhaled volume of drug mist. This is form of real-time training for users on achieving optimal inhalation, while avoiding techniques that can compromise drug delivery.

The electronic data sharing features also provide physicians and clinical study centers with additional insight into the compliance with the therapy program. They can use the data to modify the course of ongoing treatment and can more easily interpret complex study results as they happen.

Front view of black cylindrical Aptar Kolibri mesh nebulizer on mount used to deliver targeted drug product as mist to lung.

Key & Lock System for Product and Patient

Kolibri’s proprietary Key & Lock System provides product and patient protection. The Key & Lock System limits the nebulizer to only use approved aerosol head combinations that have demonstrated the ability to support robust drug delivery.

This avoids potential risk of over or underdosing that could result from the use of unauthorized or non-genuine aerosol heads. The same digital tracking systems can also measure the remaining useful life of the aerosol fill head, which can become blocked over extended use. This enables the user to replace the consumed component so that the unit continues to provide optimal drug delivery performance. The Kolibri nebulizer’s Lock & Key System also prevents the use of unauthorized generic products.

Clinical Applications

Aptar Pharma’s Kolibri vibrating mesh nebulizer systems include the CONNECT-WEB-INTERFACE features that can be used to support clinical study design. It provides a digital centralized interface that can be used to keep up with adherence monitoring from virtually anywhere with an internet connection. In addition, the Kolibri’s digital technology provides individual user inhalation quality data as well as lung performance trend information including:

Peak expiratory flow (PEF)
Forced expiratory volume (FEV1)
Forced vital capacity (FVC)

This data can help the clinical study professionals to evaluate the patient’s lung function, particularly those suffering from respiratory conditions like Asthma or Chronic Obstructive Pulmonary Disease (COPD). Kolibri’s advanced connect-web-interface helps clinical researchers with patient management responsibilities and minimizes the impact of variables on the clinical study results. By automatically selecting relevant parameters, such as flow rate of inhalation, or patient inspiration times, scientists can quickly evaluate each individual study participants data. In the end, analysis of this data can help determine if the patient’s inhalation technique was the cause of unfavorable study results or not. The digital features of Kolibri provide unique opportunities to integrate some third-party devices onto a single data platform.

Kolibri Digital Vibrating Mesh Nebulizer Advantages

Nebulizer Performance
The Teaching Nebulizer
Digital Connectivity
Sustainability

Integrated nebulizer design

Provides precise targeted nebulizer delivery of a fine mist to the lungs in an esthetically pleasing package.
Automatic feedback

Kolibri provides users with digital and haptic feedback to optimize patient technique for better compliance.
Digital data driven

Automatically uploads user data including inspiratory flow, inhalation volume and device life meter.
Multi-use nebulizer

The innovative design of the reusable nebulizer reduces the amount of plastic consumables used.

Aptar Pharma offers integrated drug delivery systems and services to advance inhalation product development. With Nanopharm’s formulation development and analytical expertise, Noble’s Human Factors support and patient onboarding, as well as Aptar Digital Health’s services, Aptar Pharma can accelerate drug formulation development, optimize device design and differentiate your product offering for improved patient outcomes.

These specialized systems and services combined with the Kolibri’s innovative digital vibrating mesh nebulizer design, makes Aptar Pharma well positioned make your next inhaled drug product concept a reality.

Contact Aptar Pharma today to start learning more about the Kolibri vibrating mesh nebulizer technology, and how it can differentiate your next product offering for OINDPs.

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Kolibri – The Digital Mesh Nebulizer System for Inhaled Drug Delivery

Kolibri – The Digital Mesh Nebulizer
System for Inhaled Drug Delivery