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Aptar Pharma has been continuously developing preservative-free-systems (PFS). Today, we offer state-of-the art technologies, knowledgeable product support and regulatory services designed support pharmaceutical customers in preparing the dispensing part of their finished product dossier.

Absolute Flexibility and Performance at Your Fingertips

 

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  • Debatable Aspects of Preservatives

    Historically used preservatives, such as benzalkonium chloride (BAC), are associated with tolerability issues in patients and can cause side effects. These can impair therapies for long-term or chronic use, e.g. glaucoma treatment in eye-care.

  • Interest for Pure Products Defines the Market

    Sea water, eucalyptus or other natural decongestants, natural eye-drops, but also prescription medicines treating serious conditions are expected to be as pure as possible. This demand creates a growing need for preservative-free solutions for multidose products.

  • Sensitivities for Dermal Treatments

    Due to skin inflammation of most chronic dermatologic diseases, additional sources of irritation -like preservatives- should be avoided. Consumers of skin preparations are used to see preservatives being eliminated from their cosmetic products (paraben).

  • Microbiological Integrity is Key

    Authorities all over the world have reacted to the obvious need for preservative-free solutions in health care and created stringent regulations and requirements when it comes to microbiological safety and integrity.

  • Pharma’s Dispensing Technologies designed to support finished product dossiers

    The Advanced-Preservative-Free system for nasal and topical use  (APF and APFPlus)as well as Aptar Pharma’s Ophthalmic Squeeze Dispenser for preservative-free eye drop delivery (OSD), are provided with a set of data and test methods designed to support pharmaceutical customers in preparing the dispensing part of their finished product dossier.

  • Setting the Benchmark in PFS Technology

    Our purely mechanical Tip-Seal technology in combination with the metal-free fluid-path of our PFSs has been developed for use without preservatives and additives such as silver ions or surface coating. As such Aptar Pharma’s preservative-free technology platform provides well-established packaging solutions for sensitive formulations as well as for preservative-free formulations.

  • Tested for Microbiological Integrity

    Along the market requirements and regulations we have developed microbial challenge procedures simulating relevant in-use scenarios. Customer formulations might require additional testing depending on the properties of their respective formulations.

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