Webinars, Pharmaceutical

Rethinking Oral Solid Dose Packaging

This session will review the sources of moisture, oxygen, and VOCs (volatile Oxygen compounds) in Oral Solid Dose blister packaging and the difference between active and barrier technology. It will discuss predictive modeling to optimize development and design and review the regulatory strategy needed for submissions

March 28, 2019 4:00 PM London / 12:00 PM New York 1 Hour
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Presented by Badre Hammond Craig Voellmicke Maria J. Krisch
28 Mar 2019

This session will review the sources of moisture, oxygen, and VOCs (volatile Oxygen compounds) in Oral Solid Dose blister packaging and the difference between active and barrier technology. It will discuss predictive modeling to optimize development and design and review the regulatory strategy needed for submissions

Presented by Badre Hammond, Director, Corporate Business Integration, Aptar Pharma, Craig Voellmicke, Vice President, Business Development, Aptar CSP and Maria J. Krisch, Ph.D., Senior Scientist, FreeThink Technologies, Inc. this webinar reviews how to improve stability, shelf-life and time to market with Activ-Blister™ technology.

Tablets and capsules are today’s most popular drug delivery forms. However, in their development, there can be stability issues associated with moisture, oxygen and reactive impurities. These challenges are likely to increase with the development of more potent API’s, larger molecules and modified release profiles. Innovative and evolving dosage forms, such as chewable and disintegrating tablets, also face heightened stability challenges and problems of shelf life. Adding to all of this, global distribution demands in zone 3/4b (hot/humid) are also increasing.

As traditional packaging options can be ineffective and/or inefficient, there is a need for new and specialized active packaging solutions to address these growing stability issues. Additionally, repetitive package design processes and drug reformulations, from stability failures, are costly and can delay product launches; improved package design tools and processes are also needed.

This webinar first looks at the sources of moisture and oxygen in oral solid dose blister packaging and the common approaches to mitigate. Then, an active desiccant and scavenger management technology (Activ-Blister™ Solutions), that will meet these challenges and help expedite time-to-market, is introduced and illustrated. To best design a blister package for specific applications, an accelerated shelf-life determination process is also presented. This process includes examination of the drug products stability over a broad range of environmental conditions to develop a predictive model for shelf life. With this data, theoretical blister designs using Activ-Blister™ Solutions are created to deliver the desired shelf life.

Presented By

Badre Hammond

VP Commercial Operations, Aptar CSP

Badre Hammond’s background is in Biochemistry with 14 years’ experience in pharmaceutical product development with focus on nasal and pulmonary drug delivery systems. Mr. Hammond has broad experience in managing development of novel drug product programs for the pharmaceutical market from formulation development, pre-clinical, CMC, to clinical phase.

Craig Voellmicke

Vice President, Business Development, Aptar CSP Technologies

Maria J. Krisch

Senior Scientist, FreeThink Technologies

Maria Krisch is a Senior Scientist at FreeThink Technologies, Inc. where she is responsible for leading company projects focused on chemical and physical stability.  Dr. Krisch received her B.A. in chemistry from Swarthmore College and her Ph.D. in physical chemistry with a focus on molecular dynamics from the University of Chicago (as an NSF Graduate Research Fellow).  She conducted post-doctoral research in physical chemistry at the University of California, Irvine, studying the surface structure and reactivity of liquids.  Dr. Krisch served on the faculty and led a research group at Trinity College in Hartford, CT for eight years before joining FreeThink Technologies, Inc. in 2017.  She is a co-author on over 20 publications.

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