Publications, Pharmaceutical

Investigation of Powder Blend Uniformity and Deposition in a Nasal Cast Using a Unit Dose Nasal Device

Interest is increasing in the use of powder formulations for nasal deposition for pain relief, disorders of the central nervous systems and vaccination. This article describes an experimental study of the deposition behavior of different blends of sumatriptan, a drug used for the treatment of migraine, with a unit dose nasal device. Blends were formulated using different lactose grades, with and without magnesium stearate, and delivered to a validated nasal cast (use courtesy of Aptar Pharma/DTF/Univ. of Tours) using a proprietary unit dose nasal device from Aptar Pharma. The results show that despite differences in cohesivity successful deposition was achieved with all model formulations at target sites such as the turbinates and olfactory region. The results demonstrate the potential utility of the unit dose nasal device.

Download Publication
1 Sep 2022

Learn more about Aptar Pharma Expertise
in Nasal Drug Delivery

Find Out More About nasal drug delivery expertise

This Might Also Be of Interest

25 May 2023

Exploring the Benefits and Future Possibilities of Nasal Drug Delivery and Drug Repos...

Webinars, Pharmaceutical, Device Innovations, Brand Differentiation, Market Insights, Product Solutions

Read More
11 May 2023

Why Pharma should care about circular packaging – Futurity leading the way

Publications, Pharmaceutical, Sustainability, Device Innovations, Brand Differentiation, Product Solutions

Read More
10 May 2023

Navigating the Development for Orally Inhaled and Nasal Drug Products

Publications, Pharmaceutical, Device Innovations, Market Insights, Product Solutions

Read More
2 May 2023

Using Intranasal Delivery for Drug Repositioning: A Compelling Proposition for Lifecy...

Publications, Pharmaceutical, Market Insights, Product Solutions, Device Innovations, Brand Differentiation

Read More
1 2 3 20
Back To Top