Publications, Pharmaceutical

Evaluating the Particle Distribution for Dry Powder Inhalers

Fluidization and disaggregation processes during dry powder inhaler use influence the aerodynamic particle size distribution, permeation, and dissolution of the active pharmaceutical ingredient(s).

This paper describes work to develop an effective test set-up to elucidate these effects by combining laser diffraction particle size distribution measurement (Spraytec) with automated imaging, via Unidose. Unidose is an apparatus developed by Nanopharm, an Aptar company. By capturing the whole impactor sized mass it enables the application of morphologically directed Raman spectroscopy to particles in the size range associated with respiratory drug delivery. Set-ups were tested with different throat models and with different commercially available dry powders inhalers. Particle size distribution data were successfully measured by laser diffraction using the developed test set-ups, and the results were compared with those generated by imaging.

Download Publication
15 Jun 2020

Learn more about Aptar Pharma Expertise
in Pulmonary Drug Delivery

Find Out More

This Might Also Be of Interest

14 Dec 2022

Building Digital Solutions To Meet The Unique Therapeutic Needs o...

Publications, Pharmaceutical, Innovation & Insights, Device Innovations, Product Solutions

Read More
25 Nov 2022

Analytical Services in the Development of MDIs and DPIs

Brochures, Pharmaceutical, Innovation & Insights, Product Solutions

Read More
16 Nov 2022

From pMDI Device to Therapeutic Effect

Webinars, Pharmaceutical, Market Insights, Product Solutions, Sustainability, Device Innovations

Read More
21 Oct 2022

Physiologically-based Pharmacokinetic Models (PBPK) for OINDPs

Publications, Pharmaceutical, Product Solutions, Device Innovations, Market Insights

Read More
1 2 3 15
Back To Top