Case Study – Unidose Nasal Spray Pump for Epilepsy

Seizure clusters, a potentially life-threatening symptom of epilepsy, can be treated by intramuscular injection with midazolam but only by a suitably trained responder. This case study describes a collaborative drug repurposing project with Aptar Pharma Services to develop a midazolam nasal spray as an easy to administer alternative, to address unmet medical need. The resulting product utilizes Aptar Pharma’s Unidose Liquid (UDS) device. Primeless and intuitive to use it can be administered by a wide range of potential carers, even to unresponsive patients. Aptar Pharma Services played an important role in optimizing the formulation for ‘nose-to-brain’ drug delivery, helping to establish a new first-in-class solution and valuable intellectual property.