Small Volume Parenteral Stoppers

Vial Components


Aptar Pharma’s Small Volume Parenteral Stoppers (Serum Stoppers) are designed for blowback and non-blowback vials and provide optimal protection and drug delivery. Our range of pharmaceutical rubber Serum Stoppers are designed to meet multiple-piercing needs and facilitate manufacturing processes.

Discover our Vial containment solutions and Injectables portfolio

Optimal Stopper Protection for Your Small Volume Drugs

Pure quality formulations with low permeability and resistance to coring

Aptar Pharma’s proprietary elastomeric formulations for stoppers are designed and manufactured to provide the highest level of quality and safety.

Thanks to our in-house expertise, we offer a variety of innovative elastomeric formulations providing optimized self-sealing, low permeability and resistance to coring, combined with high chemical inertness, which is essential for our customers’ drug products, including sensitive drug products for Biotech.

Ensuring quality protection of your drug formulation

All our proposed elastomeric formulations are compliant with international standards, such as the USP, EP, JP and ISO 8871, and are certified “not made with natural rubber”, allowing us to be your go-to drug delivery partner for all your injectable challenges. Our team of experts in our International Technical Center can support your development including the selection of designs best adapted to your vial’s requirements as well as recommendations on the right formulation for your specific applications, to ensure optimal protection of your drug product formulation.

Trusted by the world’s leading pharmaceutical companies

Our Serum Stoppers are used in over 70 countries by all the major Pharmaceutical and Biotechnology companies. Our 50+ years of experience, scientific expertise and high quality standards provide customers with a wide range of trusted injectable component solutions as well as support services, including analytical testing, regulatory support and post launch support, for drug development success.

Premium quality offering to accelerate and derisk your drug product development

Our state-of-the-art processes and our back-up factories, guarantee long-term security-of-supply. Our Small Volume Parenteral Stoppers are designed for blowback and non-blowback vials, targeting optimal protection and delivery of the drug as well as excellent machine performance. They are available in standard and textured surface finishes to mitigate compatibility issues, to help you get to market faster. Our Serum Stoppers can be delivered in different packaging and finishings options including Ready-to-Use (RTU), Ready-to-Sterilize (RTS), or PremiumFill® for improved quality processes and services, reducing contamination and compatibility issues.

Small Volume Parenteral Stopper Advantages

  • Excellent Multi-Piercing Performance
  • Optimal Compatibility and Protection
  • Good Machinability
  • Enhanced Cleanliness with PremiumFill®
  • Enhanced Protection with PremiumCoat™

Excellent self-sealing properties and low fragmentation reduces particulates

Our Serum Stoppers have been designed to facilitate multi-piercing and lower fragmentation risk thanks to pre-holes, targets and adapted flange thickness. They also have an excellent self-sealing feature.

Optimal compatibility and protection for Small Volume Parenteral applications

Our Serum Stoppers provide good chemical inertness (low extractable profile), non-cytotoxicity and low permeability ensuring maximum drug compatibility and protection throughout product life.

Adapted shapes and surface treatments

Our Serum Stoppers have anti-sticking spacers and come with either matte or rough surfaces on the flange. A rough surface improve the anti-sticking performance.

Complying with the highest quality requirements

Our Serum Stoppers are available in PremiumFill® quality, a guaranteed specification resulting in lower embedded particles, improved particulate cleanliness and an overall reduction in defects.

Compatible with your highly sensitive drug product

Our 13mm and 20mm Serum Stoppers are available in PremiumCoat®. PremiumCoat® is our range of ETFE-coated stoppers and plungers based on an approved, pure, state-of-the-art elastomeric formulation. Providing a combination of container closure integrity and improved compatibility, PremiumCoat® offers the highest standard level of guaranteed specification of particulates to protect your sensitive drugs.

Product Details

Let Our Serum Stoppers Optimally Protect Your Drugs

Contact an Aptar Pharma expert and find out how our range of Serum Stoppers for Small Volume Parenterals provide optimal protection and safety for your injectable drugs.


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